obrázek
obrázek

Products

 

Microbial lysates – for dietary supplements and cosmetics

Microbial lysates represent a new trend in keeping immunity up

Active keeping immunity strong is one the basic trends to support healthy way of live of every person. There is quite a wide offer of products supporting immunity and it is up to us which we choose. Microbial lysates exploit targeted support of immunity by means of particles of bacteria that are able to stimulate both specific and non-specific immune response. Thus they bring a unique solution to supporting immunity.


What are microbial lysates?

Microbial lysates may be an unknown term for some customers. We can imagine microbial lysates as harmless and refined particles isolated from broken bacterial cells. Due to their structure and gentle processing, these particles are able to act effectively on our immune system and to stimulate it specifically. In this case we speak about so-called immunomodulation.

 

How do microbial lysates work?

The aim of microbial lysates is to induce physiological balance of defence functions in a human body. Several researches have proved that some molecules contained in cell walls of microorganisms effectively stimulate specific and particularly non-specific immune response. Preparations containing microbial lysates are a useful supplement to support immune system in a natural way that exploits basic innate defence mechanisms.

 

Why should we use microbial lysates?

Microbial lysates are completely natural and biological immunomodulators. A human body is constantly exposed to bacteria of the environment. Supplying lysates to our body we can reinforce its immune response targeted on specific health ailments (urethrocystitis, respiratory tract infections and others). The lysates can forestall or reduce the mentioned troubles.

 

Development of products containing microbial lysates

Our current projects:

The development of products containing microbial lysates, particularly in the field of dietary supplements and cosmetics. We provide complete development of products and their registration. We have participated in development of the following preparations: FemiVaxinum Neo, RespiVaxin, DentalVaxin, NefroVaxin.



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Ultra-thin pads with probiotics and lactic acid

Microbial lysates represent a new trend in keeping immunity up

Ladies ultra-thin pads INTIMEA with probiotics and lactic acid are the result of our research and evolvement in the field of probiotics that we realized in cooperation with company FIDE, Ltd. in several years.

INTIMEA pads contain probiotics that naturally dominate microbial environment in a healthy vagina. These friendly bacteria prevent other microbes from growing by producing antimicrobial substances and lactic acid. Lactic acid maintains slightly acidic environment of the vagina, which prevents pathogenic bacteria and yeasts from overgrowing and causing vaginitis, especially mycosis. INTIMEA pads with probiotics and lactic acid are an important hygienic aid in solving problems of vaginitis. In case the inflammation has already appeared, we can supply friendly probiotics into vagina in a natural and painless way.

Who are these ultra-thin pads for?

  • for healthy women as a suitable form of stabilization of vaginal environment
  • for healthy women as a modern part of intimate hygiene during menstruation
  • for generally healthy women undergoing antibiotic treatment
  • for women who suffer from occasional vaginitis
  • for women who suffer from recurrent vaginitis
  • for women who have problems with sore or red private parts
  • for women with slight incontinence
  • for elimination of smell caused by yeasts and pathogenic bacteria

INTIMEA pads with probiotics and lactic acid are revolutionary news on the world market.


They are designated for regular use. They are vendible only in pharmacies for a very good price.

Our pads are convenient for all healthy women who want to take care of their intimate hygiene actively and who know the benefits that probiotics bring to their body. Hygienic pad is in a close contact with private parts. Its use is the most comfortable way how to supply needed friendly bacteria to vaginal mucosa. Lactic acid contained in the pad helps to maintain acidic vaginal environment, which prevents pathogenic bacteria and yeasts from growing and thus it eliminates the most frequent cause of vaginitis.


Why are INTIMEA pads suitable for women who suffer from inflammations?

INTIMEA pads with probiotics supply to vaginal environment natural bacteria which are missing due to the inflammation. A healthy vagina is dominantly populated by protective acid bacteria that prevent other microorganisms form growing. During inflammatory diseases the friendly microflora is replaced by harmful and pathogenic bacteria. They affect acidity of vaginal environment and cause unpleasant inflammation with itch, tingle and vaginal discharge. Supplying friendly probiotics to vaginal mucosa helps to restore natural vaginal balance, which is indispensable for the health of intimate parts. Lactic acid added to INTIMEA pad maintains slightly acidic environment. Thus it prevents pathogenic bacteria and yeasts from growing and causing vaginitis. Vaginitis is one the most frequent gynaecological ailment. According to statistics 75 women out of 100 has a vaginal infection at least once in their lifetime.

 

Most frequent causes of vaginal inflammation are:

  • unbalanced vaginal environment after antibiotic treatment
  • unprotected sexual intercourse with a new partner
  • infections from common pools or natural swimming pools
  • hormone imbalance during pregnancy, using of contraception
  • fatigue, lack of sleep or bad regime
  • stress
  • exposure to cold (e.g. if you keep wet swimsuit)
  • unsuitable clothes that impedes ventilation of private parts

Current antibiotic treatment is the most common cause of inflammation also for women who do not usually suffer from inflammation. Antibiotics kill not only pathogenic bacteria in our body, but also the friendly ones. Thus they upset natural bacterial balance in gastrointestinal tract and on vaginal mucosa. When the natural balance is upset, bacteria and yeasts overgrow and cause a vaginal inflammation.

Probiotics contained in INTIMEA pads help to balance the lack of friendly bacteria and they contribute to a faster recovery of vaginal environment. Lactic acid maintains acidic environment in vagina, which prevents pathogenic bacteria from growing.

 

Why are INTIMEA pads convenient for women who have problems with sore or red private parts?

INTIMEA pads contain lactic acid that contributes to calm down intimate parts.

 

Why are INTIMEA pads convenient for women with slight incontinence?

INTIMEA pads have excellent absorbency and due to probiotics and lactic acid they reduce the risk of sores and local redness.

 

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New generation of probiotics

New generation of probiotics is already the 4th generation of probiotics. Their structure is fundamentally different from the previous three generations. The previous generations contain separate, solitary cells of probiotics while the probiotics of the 4th generation bring pure bacterial culture in the form of a biofilm, i.e. in a structure similar to that one in which they occur on intestinal mucosa. Probiotic bacteria are produced and cultivated to create biofilm in order to be most functional and natural. The bacteria cultivation that results as a biofilm is a patent-protected technology.

Features of probiotics of 4th generation:

  • their structure is very close to real state in which they occur on intestinal mucosa
  • their genes are prepared to adhere quickly on intestinal epithelium
  • they are stable
  • they are more resistant to acidic pH of stomach
  • they are more resistant to selected antibiotics
  • they are more resistant to bile acid

1st – 3rd generation of probiotics and their limits

In approximately 15 years that probiotics have been on the market, they highly improved. To summarize briefly the development of probiotics, we can divide them into 3 generations:

  • 1st generation – probiotics whose bacterial cells are not processed
  • 2nd generation – enteric-coated, protected against acidic pH of the stomach
  • 3rd generation – encapsuled probiotics with elevated stability

All probiotic preparations of the 1st –3rd generation contain solitary cells.

However, the structure of bacteria in our intestine is different. If we study intestinal mucosa, we find bacteria in the form of a biofilm.

For the right function of probiotics it is necessary that they adhere to intestinal mucosa and form a so-called biofilm.

And this could be a problem. Bacteria that are cultivated as solitary cells, must be radically reprogrammed so that they are able to form a biofilm. It this does not happen, probiotic bacteria of 1st-3rd generation pass through digestive tract with no benefit.

Comparison of biofilm probiotics and commonly cultivated probiotics:

Monitored parameter Laktobacillus acidophilus as a biofilm Laktobacillus acidophilus as solitary cells
Resistance to bile in time high low
Resistance to low pH in time high low
Adhesion on surface high low
Resistance to selected antibiotics high low

The development of new generation of probiotic cultures is a result of our many years´ research in probiotics. Our newly developed product brings an absolute revolution on the market with probiotic preparations.


PROBIOLACT

Dietary supplement ProbioLact is so far the only
representative of biofilm probiotics on the market. Unique probiotic cells are present in the form of a biofilm. The biofilm is a natural and coherent layer of bacteria that create protective and stimulative barrier. This form of bacterium existence is essential for the right function of intestinal microflora. Dietary supplement ProbioLact brings an absolute revolution on the market with probiotic preparations.

 

 

 

ProbioLact contains:

Biofilm probiotics
+
Prebiotics (to stimulate the growth of beneficial microflora)
+
Vitamin C (for immunity and metabolism)
+
Special enteric-coated capsule (protection against acidic environment of stomach)

Active ingredients in 1 capsule:

Active ingredients mg /1 cps %RDI*
Lactobacillus acidophilus, 
Lactobacillus sporognes,
Bifidobacterium bifidum,
Bifidobacterium breve
Lactobacillus acidophilus hard biofilm
5 x 109 CFU** -
Vitamín C 40 50%

* RDI – Recommended daily intake – it is not determined
**CFU - colony-forming unit

 

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Antibodies for cosmetics

Revolution in cosmetics

To producers of cosmetics we offer especially production of specific IgY antibodies for ointments and creams. The antibodies can be specified against various bacteria according to our client’s demand. Antibodies in cosmetics act as an inhibitor of bacteria that cause inflammation and infection of skin. Please contact us if you are interested.


 

 

IgY antibodies can be used in several biotechnological areas:

  • pharmaceutics in the broad sense that contain not only immunological applications such as therapeutic and prophylactic ones, but also in other areas including preparation of medicines, cosmetics and others.

  • food industry specialized in functional food preparation. Its features coincide in many aspects with the previous area. Nevertheless, there is also a purely food production area where IgY antibodies can be used.
    It is preparation of safe egg products and products containing eggs that risk salmonella or campylobacter infections. It is also possible to add raw egg material containing IgY antibodies to other food that risk alimentary infections (salmonellosis, campylobateriosis, listeriosis and others), or intoxications (enterotoxin and others).

  • diagnostics, videlicet its part that works with specific antibodies. Wherever specific mammalian polyclonal antibodies are used for diagnosis, IgY antibodies can be used better. There are several reasons for their use: non-invasiveness of the procedure, better economy, significantly higher production, forementioned advantages (inactivation of mammalian complement, no connection to rheumatoid factor and mammalian antibodies ecc.). In some cases, when there are mammalian protein antibodies, phylogenetic distance allows to prepare antibodies also against molecules that immune system of mammals do not consider foreign.

  • a specific area of diagnostics where IgY antibodies could be used is detection of small amounts of antigens, whether infectious or others. Their immunoaffinity specific sorption by IgY antibodies bouned
    to solid carriers or columns would permit their detection also in amount below common detection limit.

We target the use of IgY antibodies in pharmaceutics, cosmetics and food industry in the following applications:

  • preparation designated to skin unction or for poorly healing skin sores

  • auxiliary dental products for caries prophylaxis and for prevention and treatment of stomatitis and periodontosis

  • applications on external mucosae, especially against infectious inflammations of oral, nasal, vaginal and rectal cavity. The use for animals involves prevention and treatment of mastitis and the inflammation of uterus of cattle.

  • infections of human and animal gastrointestinal tract. There is the widest range of indications where IgY can be used. Besides idiopathic viral and bacterial infections of infants and young cattle, IgY antibodies can be used for prevention and treatment of alimentary infections, for treatment of dysmicrobia including indigestion as a result of post-antibiotic effect after an overgrowth of pathogenic microflora. In this range of applications we can count also prevention and treatment of bacterial gastritides caused by Helicobacter pylori, some parasitic or protozoan infections, of which we must mention especially cryptosporidium infections.
  • infectious diseases of respiratory mucosa where antibodies are applied as a spray or by gargling if they should be effective in upper respiratory tract.

  • systemic impact in the form of injectable passive antibodies that can be administered in the same cases as polyclonal heterologous antibodies are. Especially there are antisera against toxins whether they are bacterial (tetanus, verotoxin and others) or animal toxins (snake or insect venoms and others). Compared to so far used animal sera, the use of IgY antibodies would have many advantages. In consideration of difficulties with marketing of such products, their preparation is not recommended yet.

Completed research project of our firm in cooperation with Favea company concerns external application of IgY antibodies on skin infections or for treatment of poorly healing skin sores.


This use of IgY antibodies lies between prevention and treatment application on one hand and cosmetic approach on the other hand. In both cases we try to stop or forestall pathogenic microorganism infection. The most frequent causative organisms of skin infection are staphylococci (Staphylococcus aureus and Staph. epidermidis) and Propionibacterium acnes. We have successfully completed the project of preventive use of IgY antibodies against these microorganisms.